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KMID : 0356620020170020263
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Journal of Korean Society of Endocrinology
2002 Volume.17 No. 2 p.263 ~ p.268
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A Case of Anterior Pituitary Agenesis in an Adult Woman
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Jung Tae-Sik
Hahm Jong-Ryeal
Lee Kang-Wan
Jung Jung-Hwa
Kim Soo-Hee
Ha Jong
Cho Hwal-Suk
Chung Soon-Il
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Abstract
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Dear Author,You have used abbreviations that will need to be defined in the main paper, i.e. PIT1, PROP1 and MRI. This is just for your advice. Pituitary agenesis is an uncommon cause of panhypopituitarism. It has been proposed that breech delivery, or birth trauma, is a major factor causing pituitary agenesis. Recent studies have suggested that genetic defects in the PIT1 or PROP1 gene might be involved in the pathogenesis of pituitary agenesis. In this case we report on the diagnosis of a 33-years old female patient with- growth retardation and sexual infantilism. We diagnosed anterior pituitary hormones deficiencies, with the exception of adrenocorticotropic hormone, by a combined pituitary stimulation test. We observed pituitary agenesis using sella MRI. Involvement of the PIT1 or PROP1 genes in this case remains to be determined. Here we report a case of pituitary agenesis found in an adult woman together with a brief review about this disease entity.
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KEYWORD
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Hypopituitarism, Pituitary agenesis, PROP1 gene
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